TY - JOUR T1 - Information Processing by Simple Molecular Motifs and Susceptibility to Noise JF - bioRxiv DO - 10.1101/023697 SP - 023697 AU - Siobhan McMahon AU - Oleg Lenive AU - Sarah Filippi AU - Michael P.H. Stumpf Y1 - 2015/01/01 UR - http://biorxiv.org/content/early/2015/07/31/023697.abstract N2 - Biological organisms rely on their ability to sense and respond appropriately to their environment. The molecular mechanisms that facilitate these essential processes are however subject to a range of random effects and stochastic processes, which jointly affect the reliability of information transmission between receptors and e.g. the physiological downstream response. Information is mathematically defined in terms of the entropy; and the extent of information flowing across an information channel or signalling system is typically measured by the “mutual information”, or the reduction in the uncertainty about the output once the input signal is known. Here we quantify how extrinsic and intrinsic noise affect the transmission of simple signals along simple motifs of molecular interaction networks. Even for very simple systems the effects of the different sources of variability alone and in combination can give rise to bewildering complexity. In particular extrinsic variability is apt to generate “apparent” information that can in extreme cases mask the actual information that for a single system would flow between the different molecular components making up cellular signalling pathways. We show how this artificial inflation in apparent information arises and how the effects of different types of noise alone and in combination can be understood. ER -