RT Journal Article
SR Electronic
T1 Hybrid-Lambda: simulation of multiple merger and Kingman gene genealogies in species networks and species trees
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 023465
DO 10.1101/023465
A1 Sha Zhu
A1 James H. Degnan
A1 Sharyn J. Goldstien
A1 Bjarki Eldon
YR 2015
UL http://biorxiv.org/content/early/2015/07/29/023465.abstract
AB Background There has been increasing interest in coalescent models which admit multiple mergers of ancestral lineages; and to model hybridization and coalescence simultaneously.Results Hybrid-Lambda is a software package that simulates gene genealogies under multiple merger and Kingman’s coalescent processes within species networks or species trees. Hybrid-Lambda allows different coalescent processes to be specified for different populations, and allows for time to be converted between generations and coalescent units, by specifying a population size for each population. In addition, Hybrid-Lambda can generate simulated datasets, assuming the infinitely many sites mutation model, and compute the FST statistic. As an illustration, we apply Hybrid-Lambda to infer the time of subdivision of certain marine invertebrates under different coalescent processes.Conclusions Hybrid-Lambda makes it possible to investigate biogeographic concordance among high fecundity species exhibiting skewed offspring distribution.