RT Journal Article
SR Electronic
T1 Reconstructing A/B compartments as revealed by Hi-C using long-range correlations in epigenetic data
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 019000
DO 10.1101/019000
A1 Jean-Philippe Fortin
A1 Kasper D. Hansen
YR 2015
UL http://biorxiv.org/content/early/2015/06/03/019000.abstract
AB Analysis of Hi-C data has shown that the genome can be divided into two compartments called A/B compartments. These compartments are cell-type specific and are associated with open and closed chromatin. We show that A/B compartments can be reliably estimated using epigenetic data from several different platforms, the Illumina 450k DNA methylation microarray, DNase hypersensitivity sequencing, single-cell ATAC sequencing and single-cell whole-genome bisulfite sequencing. We do this by exploiting the fact that the structure of long range correlations differs between open and closed compartments. This work makes A/B compartments readily available in a wide variety of cell types, including many human cancers.