TY - JOUR T1 - Reconstructing A/B compartments as revealed by Hi-C using long-range correlations in epigenetic data JF - bioRxiv DO - 10.1101/019000 SP - 019000 AU - Jean-Philippe Fortin AU - Kasper D. Hansen Y1 - 2015/01/01 UR - http://biorxiv.org/content/early/2015/06/03/019000.abstract N2 - Analysis of Hi-C data has shown that the genome can be divided into two compartments called A/B compartments. These compartments are cell-type specific and are associated with open and closed chromatin. We show that A/B compartments can be reliably estimated using epigenetic data from several different platforms, the Illumina 450k DNA methylation microarray, DNase hypersensitivity sequencing, single-cell ATAC sequencing and single-cell whole-genome bisulfite sequencing. We do this by exploiting the fact that the structure of long range correlations differs between open and closed compartments. This work makes A/B compartments readily available in a wide variety of cell types, including many human cancers. ER -