@article {Fortin019000, author = {Jean-Philippe Fortin and Kasper D. Hansen}, title = {Reconstructing A/B compartments as revealed by Hi-C using long-range correlations in epigenetic data}, elocation-id = {019000}, year = {2015}, doi = {10.1101/019000}, publisher = {Cold Spring Harbor Laboratory}, abstract = {Analysis of Hi-C data has shown that the genome can be divided into two compartments called A/B compartments. These compartments are cell-type specific and are associated with open and closed chromatin. We show that A/B compartments can be reliably estimated using epigenetic data from several different platforms, the Illumina 450k DNA methylation microarray, DNase hypersensitivity sequencing, single-cell ATAC sequencing and single-cell whole-genome bisulfite sequencing. We do this by exploiting the fact that the structure of long range correlations differs between open and closed compartments. This work makes A/B compartments readily available in a wide variety of cell types, including many human cancers.}, URL = {https://www.biorxiv.org/content/early/2015/06/03/019000}, eprint = {https://www.biorxiv.org/content/early/2015/06/03/019000.full.pdf}, journal = {bioRxiv} }