RT Journal Article
SR Electronic
T1 Genomic epidemiology of the current wave of artemisinin resistant malaria
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 019737
DO 10.1101/019737
A1 Roberto Amato
A1 Olivo Miotto
A1 Charles Woodrow
A1 Jacob Almagro-Garcia
A1 Ipsita Sinha
A1 Susana Campino
A1 Daniel Mead
A1 Eleanor Drury
A1 Mihir Kekre
A1 Mandy Sanders
A1 Alfred Amambua-Ngwa
A1 Chanaki Amaratunga
A1 Lucas Amenga-Etego
A1 Tim J C Anderson
A1 Voahangy Andrianaranjaka
A1 Tobias Apinjoh
A1 Elizabeth Ashley
A1 Sarah Auburn
A1 Gordon A Awandare
A1 Vito Baraka
A1 Alyssa Barry
A1 Maciej F Boni
A1 Steffen Borrmann
A1 Teun Bousema
A1 Oralee Branch
A1 Peter C Bull
A1 Kesinee Chotivanich
A1 David J Conway
A1 Alister Craig
A1 Nicholas P Day
A1 Abdoulaye Djimdé
A1 Christiane Dolecek
A1 Arjen M Dondorp
A1 Chris Drakeley
A1 Patrick Duffy
A1 Diego F Echeverri-Garcia
A1 Thomas G Egwang
A1 Rick M Fairhurst
A1 Abul Faiz, Md.
A1 Caterina I Fanello
A1 Tran Tinh Hien
A1 Abraham Hodgson
A1 Mallika Imwong
A1 Deus Ishengoma
A1 Pharath Lim
A1 Chanthap Lon
A1 Jutta Marfurt
A1 Kevin Marsh
A1 Mayfong Mayxay
A1 Victor Mobegi
A1 Olugbenga Mokuolu
A1 Jacqui Montgomery
A1 Ivo Mueller
A1 Myat Phone Kyaw
A1 Paul N Newton
A1 Francois Nosten
A1 Rintis Noviyanti
A1 Alexis Nzila
A1 Harold Ocholla
A1 Abraham Oduro
A1 Marie Onyamboko
A1 Jean-Bosco Ouedraogo
A1 Aung Pyae Phyo
A1 Christopher V Plowe
A1 Ric N Price
A1 Sasithon Pukrittayakamee
A1 Milijaona Randrianarivelojosia
A1 Pascal Ringwald
A1 Lastenia Ruiz
A1 David Saunders
A1 Alex Shayo
A1 Peter Siba
A1 Shannon Takala-Harrison
A1 Thuy-Nhien Nguyen Thanh
A1 Vandana Thathy
A1 Federica Verra
A1 Nicholas J White
A1 Ye Htut
A1 Victoria J Cornelius
A1 Rachel Giacomantonio
A1 Dawn Muddyman
A1 Christa Henrichs
A1 Cinzia Malangone
A1 Dushyanth Jyothi
A1 Richard D Pearson
A1 Julian C Rayner
A1 Gilean McVean
A1 Kirk Rockett
A1 Alistair Miles
A1 Paul Vauterin
A1 Ben Jeffery
A1 Magnus Manske
A1 Jim Stalker
A1 Bronwyn MacInnis
A1 Dominic P Kwiatkowski
A1 MalariaGEN Plasmodium falciparum Community Project
YR 2015
UL http://biorxiv.org/content/early/2015/05/24/019737.abstract
AB Artemisinin resistant Plasmodium falciparum is advancing across Southeast Asia in a soft selective sweep involving at least 20 independent kelch13 mutations. In a large global survey, we find that kelch13 mutations which cause resistance in Southeast Asia are present at low frequency in Africa. We show that African kelch13 mutations have originated locally, and that kelch13 shows a normal variation pattern relative to other genes in Africa, whereas in Southeast Asia there is a great excess of non-synonymous mutations, many of which cause radical amino-acid changes. Thus, kelch13 is not currently undergoing strong selection in Africa, despite a deep reservoir of standing variation that could potentially allow resistance to emerge rapidly. The practical implications are that public health surveillance for artemisinin resistance should not rely on kelch13 data alone, and interventions to prevent resistance must account for local evolutionary conditions, shown by genomic epidemiology to differ greatly between geographical regions.