%0 Journal Article %A Carlotta De Filippo %A Monica Di Paola %A Irene Stefanini %A Lisa Rizzetto %A Luisa Berná %A Matteo Ramazzotti %A Leonardo Dapporto %A Damariz Rivero %A Ivo G. Gut %A Marta Gut %A Mónica Bayés %A Jean-Luc Legras %A Roberto Viola %A Cristina Massi-Benedetti %A Antonella De Luca %A Luigina Romani %A Paolo Lionetti %A Duccio Cavalieri %T Population genomics of Saccharomyces cerevisiae human isolates: passengers, colonizers, invaders %D 2014 %R 10.1101/001891 %J bioRxiv %P 001891 %X The quest for the ecological niches of Saccharomyces cerevisiae ranged from wineries to oaks and more recently to the gut of Crabro Wasps. Here we propose the role of the human gut in shaping S. cerevisiae evolution, presenting the genetic structure of a previously unknown population of yeasts, associated with Crohn’s disease, providing evidence for clonal expansion within human’s gut. To understand the role of immune function in the human-yeast interaction we classified strains according to their immunomodulatory properties, discovering a set of genetically homogeneous isolates, capable of inducing anti-inflammatory signals via regulatory T cells proliferation, and on the contrary, a positive association between strain mosaicism and ability to elicit inflammatory, IL-17 driven, immune responses. The approach integrating genomics with immune phenotyping showed selection on genes involved in sporulation and cell wall remodeling as central for the evolution of S. cerevisiae Crohn’s strains from passengers to commensals to potential pathogens. %U https://www.biorxiv.org/content/biorxiv/early/2014/01/17/001891.full.pdf