TY - JOUR T1 - HiFive: A tool suite for easy and efficient HiC and 5C data analysis JF - bioRxiv DO - 10.1101/009951 SP - 009951 AU - Michael EG Sauria AU - Jennifer E Phillips-Cremins AU - Victor G Corces AU - James Taylor Y1 - 2015/01/01 UR - http://biorxiv.org/content/early/2015/05/08/009951.abstract N2 - The chromatin interaction assays 5C and HiC have advanced our understanding of genomic spatial organization but analysis approaches for these data are limited by usability and flexibility. The HiFive tool suite provides efficient data handling and a variety of normalization approaches for easy, fast analysis and method comparison. Integration of MPI-based parallelization allows scalability and rapid processing time. In addition to single-command analysis of an entire experiment from mapped reads to interaction values, HiFive has been integrated into the open-source, web-based platform Galaxy to connect users with computational resources and a graphical interface. HiFive is available from http://taylorlab.org/software/hifive/ and https://github.com/bxlab/hifive. ER -