PT  - JOURNAL ARTICLE
AU  - Kian-Hin Tan
AU  - Kok-Gan Chan
TI  - Genome analysis leads to discovery of Quorum Sensing Genes in <em>Cedecea neteri</em>
AID  - 10.1101/018887
DP  - 2015 Jan 01
TA  - bioRxiv
PG  - 018887
4099  - http://biorxiv.org/content/early/2015/05/03/018887.short
4100  - http://biorxiv.org/content/early/2015/05/03/018887.full
AB  - We have identified a strain of C. neteri SSMD04 isolated from pickled mackerel sashimi that produced N-acyl-homoserine lactone (AHL) type quorum sensing (QS) activity. Tandem mass sspectrometry revealed that C. neteri SSMD04 produced N-butyryl-homoserine lactone (C4-HSL). We identified a pair of luxIR homologues in this genome that shares the highest similarity with croIR from Citrobacter rodentium. The AHL synthase, which we named it as cneI (636 bp) and at 8bp distance from cneI is a sequence encoding a hypothetical protein, potentially the cognate receptor, a luxR homologue which we named it as cneR. We also found an orphan luxR in this isolate. To our knowledge, this is the first report on the AHL production activity in C. neteri, discovery of its luxI/R homologues and the orphan receptor.