TY - JOUR T1 - Risk of vascular events or death in different manifestations of cerebral small vessel disease: a 2-year follow-up study with a control group JF - bioRxiv DO - 10.1101/151498 SP - 151498 AU - Jacek Staszewski, MD PhD AU - Renata Piusińska-Macoch, PhD AU - Bogdan Brodacki, MD PhD AU - Ewa Skrobowska, MD PhD AU - Katarzyna Macek MD AU - Adam Stępień, MD PhD Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/06/18/151498.abstract N2 - Background and Purpose Natural course of cerebral small vessel disease (CSVD) has not yet been thoroughly studied. The aim of the single center study was to establish risk of vascular events or death in different manifestations of CSVD.Methods 150 consecutive, functionally independent patients with marked MRI features of CSVD and with recent lacunar stroke (n=52, LS), 20 with deep hemorrhagic stroke (HS), 28 with vascular parkinsonism (VaP), 50 with vascular dementia (VaD) and 55 controls (CG) with high atherothrombotic risk free of cerebrovascular events were prospectively recruited and followed for 24 months.Results Mean age and sex distribution were similar in CSVD and CG but patients with CSVD were less likely to have CAD (19% vs 40%, p=0,02) and tended to have higher prevalence of diabetes (54% vs 37%, p=0,11). The risk of vascular events or death was increased in CSVD (4,56; 95%CI 1,3-14,9) vs CG, in patients with moderate to severe white matter lesions at baseline MRI (HR 2,0; 95%CI 0,85-7,2), and it was similar in LS and HS (HR 4,70; 95%CI 1,3- 16,2) and VaD and VaP (HR 4,59; 95%CI 1,3-15,7).Conclusions Patients with symptomatic CSVD regardless of the clinical (acute or chronic) manifestation had more than fourfold the risk of vascular events or death in 24 months of observation compared with controls with high atherothrombotic risk free of cerebrovascular events. ER -