TY - JOUR T1 - Just above chance: is it harder to decode information from human prefrontal cortex BOLD signals? JF - bioRxiv DO - 10.1101/127324 SP - 127324 AU - Apoorva Bhandari AU - Christopher Gagne AU - David Badre Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/06/16/127324.abstract N2 - Understanding the nature and form of prefrontal cortex representations that support flexible behavior is an important open problem in cognitive neuroscience. In humans, multi-voxel pattern analysis (MVPA) of fMRI BOLD measurements has emerged as an important approach for studying neural representations. An implicit, untested assumption underlying many PFC MVPA studies is that the base rate of decoding information from PFC BOLD activity patterns is similar to that of other brain regions. Here we estimate these base rates from a meta-analysis of published MVPA studies and show that the PFC has a significantly lower base rate for decoding than visual sensory cortex. Our results have implications for the design and interpretation of MVPA studies of prefrontal cortex, and raise important questions about its functional organization. ER -