@article {Shvetsov150664, author = {Alexey V. Shvetsov and Yana A. Zabrodskaya and Peter A. Nekrasov and Vladimir V. Egorov}, title = {Triazavirine supramolecular complexes as modifiers of the peptide oligomeric structure}, elocation-id = {150664}, year = {2017}, doi = {10.1101/150664}, publisher = {Cold Spring Harbor Laboratory}, abstract = {In this study we present molecular dynamics simulations of the antiviral drug triazavirine, that affects formation of amyloid-like fibrils of the model peptide (SI). According to our simulations, triazavirine is able to form linear supramolecular structures which can act as shields and prevent interactions between SI monomers. This model, as validated by simulations, provides an adequate explanation of triazavirine{\textquoteright}s mechanism of action as it pertains to SI peptide fibril formation.}, URL = {https://www.biorxiv.org/content/early/2017/06/16/150664}, eprint = {https://www.biorxiv.org/content/early/2017/06/16/150664.full.pdf}, journal = {bioRxiv} }