RT Journal Article
SR Electronic
T1 Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 140475
DO 10.1101/140475
A1 David Tamborero
A1 Carlota Rubio-Perez
A1 Jordi Deu-Pons
A1 Michael P Schroeder
A1 Ana Vivancos
A1 Ana Rovira
A1 Ignasi Tusquets
A1 Joan Albanell
A1 Jordi Rodon
A1 Josep Tabernero
A1 Carmen de Torres
A1 Rodrigo Dienstmann
A1 Abel Gonzalez-Perez
A1 Nuria Lopez-Bigas
YR 2017
UL http://biorxiv.org/content/early/2017/06/13/140475.abstract
AB While tumor genome sequencing has become widely available in clinical and research settings, the interpretation of tumor somatic variants remains an important bottleneck. Most of the alterations observed in tumors, including those in well-known cancer genes, are of uncertain significance. Moreover, the information on tumor genomic alterations shaping the response to existing therapies is fragmented across the literature and several specialized resources. Here we present the Cancer Genome Interpreter (http://www.cancergenomeinterpreter.org), an open access tool that we have implemented to annotate genomic alterations and interpret their possible role in tumorigenesis and in the response to anti-cancer therapies.