TY - JOUR T1 - Genetics of the Research Domain Criteria (RDoC): genome-wide association study of delay discounting JF - bioRxiv DO - 10.1101/146936 SP - 146936 AU - Sandra Sanchez-Roige AU - Pierre Fontanillas AU - Sarah L. Elson AU - the 23andMe Research Team AU - Anita Pandit AU - Ellen Schmidt AU - Johanna Forster AU - Goncalo R. Abecasis AU - Joshua C. Gray AU - Harriet de Wit AU - Lea K. Davis AU - James MacKillop AU - Abraham A. Palmer Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/06/07/146936.abstract N2 - Delay discounting (DD), or the tendency to favor immediate over future rewards, is a form of impulsivity that is present in a constellation of diseases. Here we performed a genome-wide association study of DD using 23,127 research participants of European ancestry. We estimated chip heritability at 12%, and identified significant genetic correlations between DD and neuropsychiatric diseases (attention-deficit/hyperactivity disorder (ADHD), schizophrenia, major depression), smoking, personality, cognition, and weight. ER -