RT Journal Article
SR Electronic
T1 Genetics of the Research Domain Criteria (RDoC): genome-wide association study of delay discounting
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 146936
DO 10.1101/146936
A1 Sandra Sanchez-Roige
A1 Pierre Fontanillas
A1 Sarah L. Elson
A1 the 23andMe Research Team
A1 Anita Pandit
A1 Ellen Schmidt
A1 Johanna Forster
A1 Goncalo R. Abecasis
A1 Joshua C. Gray
A1 Harriet de Wit
A1 Lea K. Davis
A1 James MacKillop
A1 Abraham A. Palmer
YR 2017
UL http://biorxiv.org/content/early/2017/06/07/146936.abstract
AB Delay discounting (DD), or the tendency to favor immediate over future rewards, is a form of impulsivity that is present in a constellation of diseases. Here we performed a genome-wide association study of DD using 23,127 research participants of European ancestry. We estimated chip heritability at 12%, and identified significant genetic correlations between DD and neuropsychiatric diseases (attention-deficit/hyperactivity disorder (ADHD), schizophrenia, major depression), smoking, personality, cognition, and weight.