TY - JOUR T1 - A large-scale circuit mechanism for hierarchical dynamical processing in the primate cortex JF - bioRxiv DO - 10.1101/017137 SP - 017137 AU - Rishidev Chaudhuri AU - Kenneth Knoblauch AU - Marie-Alice Gariel AU - Henry Kennedy AU - Xiao-Jing Wang Y1 - 2015/01/01 UR - http://biorxiv.org/content/early/2015/03/26/017137.abstract N2 - We developed a large-scale dynamical model of the macaque neocortex based on recent quantitative connectivity data. A hierarchy of timescales naturally emerges from this system: sensory areas show brief, transient responses to input (appropriate for sensory processing), whereas association areas integrate inputs over time and exhibit persistent activity (suitable for decision-making and working memory). The model displays multiple temporal hierarchies, as evidenced by contrasting responses to visual and somatosensory stimulation. Moreover, slower prefrontal and temporal areas have a disproportionate impact on global brain dynamics. These findings establish for the first time a circuit mechanism for “temporal receptive windows” that are progressively enlarged along the cortical hierarchy, extend the concept of working memory from local to large circuits, and suggest a re-interpretation of functional connectivity measures.Conflict of Interest The authors declare no competing financial interests.Acknowledgements We thank Nikola Markov and John Murray for discussions. This work was supported by ONR grant N00014-13-1-0297 and NIH grant R01MH062349 (X.-J.W.) and by ANR-11-BSV4-501 and LABEX CORTEX (ANR-11-LABX-0042) of Université de Lyon, program “Investissements d’Avenir” (ANR-11-IDEX-0007) operated by the French National Research Agency (H.K.). The connectivity data is available at www.core-nets.org. ER -