TY - JOUR T1 - Swapping of transmembrane domains in the epithelial calcium channel TRPV6 JF - bioRxiv DO - 10.1101/141523 SP - 141523 AU - Appu K. Singh AU - Kei Saotome AU - Alexander I. Sobolevsky Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/05/24/141523.abstract N2 - Tetrameric ion channels have either swapped or non-swapped arrangements of the S1-S4 and pore domains. Here we show that mutations in the transmembrane domain of TRPV6 can result in conversion from a domain-swapped to non-swapped fold. These results reveal structural determinants of domain swapping and raise the possibility that a single ion channel subtype can fold into either arrangement in vivo, affecting its function in normal or disease states. ER -