RT Journal Article
SR Electronic
T1 Swapping of transmembrane domains in the epithelial calcium channel TRPV6
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 141523
DO 10.1101/141523
A1 Appu K. Singh
A1 Kei Saotome
A1 Alexander I. Sobolevsky
YR 2017
UL http://biorxiv.org/content/early/2017/05/24/141523.abstract
AB Tetrameric ion channels have either swapped or non-swapped arrangements of the S1-S4 and pore domains. Here we show that mutations in the transmembrane domain of TRPV6 can result in conversion from a domain-swapped to non-swapped fold. These results reveal structural determinants of domain swapping and raise the possibility that a single ion channel subtype can fold into either arrangement in vivo, affecting its function in normal or disease states.