PT - JOURNAL ARTICLE AU - Appu K. Singh AU - Kei Saotome AU - Alexander I. Sobolevsky TI - Swapping of transmembrane domains in the epithelial calcium channel TRPV6 AID - 10.1101/141523 DP - 2017 Jan 01 TA - bioRxiv PG - 141523 4099 - http://biorxiv.org/content/early/2017/05/24/141523.short 4100 - http://biorxiv.org/content/early/2017/05/24/141523.full AB - Tetrameric ion channels have either swapped or non-swapped arrangements of the S1-S4 and pore domains. Here we show that mutations in the transmembrane domain of TRPV6 can result in conversion from a domain-swapped to non-swapped fold. These results reveal structural determinants of domain swapping and raise the possibility that a single ion channel subtype can fold into either arrangement in vivo, affecting its function in normal or disease states.