RT Journal Article
SR Electronic
T1 A statistical mechanics model for the collective epigenetic histone modification dynamics
JF bioRxiv
FD Cold Spring Harbor Laboratory Press
SP 001693
DO 10.1101/001693
A1 Hang Zhang
A1 XIAO-JUN TIAN
A1 Abhishek Mukhopadhyay
A1 Kenneth S Kim
A1 Jianhua Xing
YR 2014
UL http://biorxiv.org/content/early/2014/01/08/001693.abstract
AB Epigenetic histone modifications play an important role in the maintenance of different cell phenotypes. The exact molecular mechanism for inheritance of the modification patterns over cell generations remains elusive. We construct a Potts-type model based on experimentally observed nearest-neighbor enzyme lateral interactions and nucleosome covalent modification state biased enzyme recruitment. The model can lead to effective nonlocal interactions among nucleosomes suggested in previous theoretical studies, and epigenetic memory is robustly inheritable against stochastic cellular processes.