TY - JOUR T1 - A statistical mechanics model for the collective epigenetic histone modification dynamics JF - bioRxiv DO - 10.1101/001693 SP - 001693 AU - Hang Zhang AU - XIAO-JUN TIAN AU - Abhishek Mukhopadhyay AU - Kenneth S Kim AU - Jianhua Xing Y1 - 2014/01/01 UR - http://biorxiv.org/content/early/2014/01/08/001693.abstract N2 - Epigenetic histone modifications play an important role in the maintenance of different cell phenotypes. The exact molecular mechanism for inheritance of the modification patterns over cell generations remains elusive. We construct a Potts-type model based on experimentally observed nearest-neighbor enzyme lateral interactions and nucleosome covalent modification state biased enzyme recruitment. The model can lead to effective nonlocal interactions among nucleosomes suggested in previous theoretical studies, and epigenetic memory is robustly inheritable against stochastic cellular processes. ER -