RT Journal Article
SR Electronic
T1 Ionic current correlations are ubiquitous across phyla
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 137133
DO 10.1101/137133
A1 Trinh Tran
A1 Cagri T. Unal
A1 Laszlo Zaborszky
A1 Horacio Rotstein
A1 Alfredo Kirkwood
A1 Jorge Golowasch
YR 2017
UL http://biorxiv.org/content/early/2017/05/12/137133.abstract
AB Ionic currents, whether measured as conductance amplitude or as ion channel transcript levels, can vary many-fold within a population of identified neurons. This variability has been observed in multiple invertebrate neuronal types, but they do so in a coordinated manner such that their magnitudes are correlated. These conductance correlations are thought to reflect a tight homeostasis of cellular excitability that enhances the robustness and stability of neuronal activity over long stretches of time. Notably, although such ionic current correlations are well documented in invertebrates, they have not been reported in vertebrates. Here we demonstrate with two examples, identified mouse hippocampal granule cells and cholinergic basal forebrain neurons, that ionic current correlations is a ubiquitous phenomenon expressed by a number of species across phyla.