TY - JOUR T1 - Ionic current correlations are ubiquitous across phyla JF - bioRxiv DO - 10.1101/137133 SP - 137133 AU - Trinh Tran AU - Cagri T. Unal AU - Laszlo Zaborszky AU - Horacio Rotstein AU - Alfredo Kirkwood AU - Jorge Golowasch Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/05/12/137133.abstract N2 - Ionic currents, whether measured as conductance amplitude or as ion channel transcript levels, can vary many-fold within a population of identified neurons. This variability has been observed in multiple invertebrate neuronal types, but they do so in a coordinated manner such that their magnitudes are correlated. These conductance correlations are thought to reflect a tight homeostasis of cellular excitability that enhances the robustness and stability of neuronal activity over long stretches of time. Notably, although such ionic current correlations are well documented in invertebrates, they have not been reported in vertebrates. Here we demonstrate with two examples, identified mouse hippocampal granule cells and cholinergic basal forebrain neurons, that ionic current correlations is a ubiquitous phenomenon expressed by a number of species across phyla. ER -