RT Journal Article
SR Electronic
T1 The Human Cell Atlas
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 121202
DO 10.1101/121202
A1 Aviv Regev
A1 Sarah A. Teichmann
A1 Eric S. Lander
A1 Ido Amit
A1 Christophe Benoist
A1 Ewan Birney
A1 Bernd Bodenmiller
A1 Peter Campbell
A1 Piero Carninci
A1 Menna Clatworthy
A1 Hans Clevers
A1 Bart Deplancke
A1 Ian Dunham
A1 James Eberwine
A1 Roland Eils
A1 Wolfgang Enard
A1 Andrew Farmer
A1 Lars Fugger
A1 Berthold Göttgens
A1 Nir Hacohen
A1 Muzlifah Haniffa
A1 Martin Hemberg
A1 Seung Kim
A1 Paul Klenerman
A1 Arnold Kriegstein
A1 Ed Lein
A1 Sten Linnarsson
A1 Joakim Lundeberg
A1 Partha Majumder
A1 John C. Marioni
A1 Miriam Merad
A1 Musa Mhlanga
A1 Martijn Nawijn
A1 Mihai Netea
A1 Garry Nolan
A1 Dana Pe’er
A1 Anthony Phillipakis
A1 Chris P. Ponting
A1 Steve Quake
A1 Wolf Reik
A1 Orit Rozenblatt-Rosen
A1 Joshua Sanes
A1 Rahul Satija
A1 Ton N. Schumacher
A1 Alex Shalek
A1 Ehud Shapiro
A1 Padmanee Sharma
A1 Jay W. Shin
A1 Oliver Stegle
A1 Michael Stratton
A1 Michael J. T. Stubbington
A1 Alexander van Oudenaarden
A1 Allon Wagner
A1 Fiona Watt
A1 Jonathan Weissman
A1 Barbara Wold
A1 Ramnik Xavier
A1 Nir Yosef
A1 the Human Cell Atlas Meeting Participants
YR 2017
UL http://biorxiv.org/content/early/2017/05/08/121202.abstract
AB The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the 150-year-old effort to identify all cell types in the human body, by undertaking a Human Cell Atlas Project as an international collaborative effort. The aim would be to define all human cell types in terms of distinctive molecular profiles (e.g., gene expression) and connect this information with classical cellular descriptions (e.g., location and morphology). A comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, as well as provide a framework for understanding cellular dysregulation in human disease. Here we describe the idea, its potential utility, early proofs-of-concept, and some design considerations for the Human Cell Atlas.