RT Journal Article
SR Electronic
T1 Precision Medicine Screening Using Whole Genome Sequencing and Advanced Imaging To Identify Disease Risk in Adults
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 133538
DO 10.1101/133538
A1 Bradley A Perkins
A1 C. Thomas Caskey
A1 Pamila Brar
A1 Eric Dec
A1 David Karow
A1 Andrew Kahn
A1 Claire Hou
A1 Naisha Shah
A1 Debbie Boeldt
A1 Erin Coughlin
A1 Gabby Hands
A1 Victor Lavrenko
A1 James Yu
A1 Andrea Procko
A1 Julia Appis
A1 Anders Dale
A1 Lining Guo
A1 Thomas J. Jönsson
A1 Bryan M. Wittmann
A1 Istvan Bartha
A1 Smriti Ramakrishnan
A1 Axel Bernal
A1 James Brewer
A1 Suzanne Brewerton
A1 William H Biggs
A1 Yaron Turpaz
A1 Amalio Telenti
A1 J Craig Venter
YR 2017
UL http://biorxiv.org/content/early/2017/05/03/133538.abstract
AB BACKGROUND Progress in science and technology have created the capabilities and alternatives to symptom-driven medical care. Reducing premature mortality associated with age-related chronic diseases, such as cancer and cardiovascular disease, is an urgent priority we address using advanced screening detection.METHODS We enrolled active adults for early detection of risk for age-related chronic disease associated with premature mortality. Whole genome sequencing together with: global metabolomics, 3D/4D imaging using non-contrast whole body magnetic resonance imaging and echocardiography, and 2-week cardiac monitoring were employed to detect age-related chronic diseases and risk for diseases.RESULTS We detected previously unrecognized age-related chronic diseases requiring prompt (<30 days) medical attention in 17 (8%, 1:12) of 209 study participants, including 4 participants with early stage neoplasms (2%, 1:50). Likely mechanistic genomic findings correlating with clinical data were identified in 52 participants (25%. 1:4). More than three-quarters of participants (n=164, 78%, 3:4) had evidence of age-related chronic diseases or associated risk factors.CONCLUSIONS Precision medicine screening using genomics with other advanced clinical data among active adults identified unsuspected disease risks for age-related chronic diseases associated with premature mortality. This technology-driven phenotype screening approach has the potential to extend healthy life among active adults through improved early detection and prevention of age-related chronic diseases. Our success provides a scalable strategy to move medical practice and discovery toward risk detection and disease modification thus achieving healthier extension of life.SIGNIFICANCE STATEMENT Advances in science and technology have enabled scientists to analyze the human genome cost-effectively and to combine genome sequencing with noninvasive imaging technologies for alternatives to symptom-driven medical care. Using whole genome sequencing and noninvasive 3D/4D imaging technologies we screened 209 adults to detect age-related chronic diseases, such as cancer and cardiovascular disease. We found unrecognized age-related chronic diseases requiring prompt (<30 days) medical attention in 1:12 study participants, likely genomic findings correlating with clinical data in 1:4 participants, and evidence of age-related chronic diseases or associated risk factors in more than 3 of 4 participants. These results demonstrate that genome sequencing with clinical imaging data can be used for screening and early detection of diseases associated with premature mortality.