RT Journal Article
SR Electronic
T1 Ancient human genomes suggest three ancestral populations for present-day Europeans
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 001552
DO 10.1101/001552
A1 Iosif Lazaridis
A1 Nick Patterson
A1 Alissa Mittnik
A1 Gabriel Renaud
A1 Swapan Mallick
A1 Peter H. Sudmant
A1 Joshua G. Schraiber
A1 Sergi Castellano
A1 Karola Kirsanow
A1 Christos Economou
A1 Ruth Bollongino
A1 Qiaomei Fu
A1 Kirsten I. Bos
A1 Susanne Nordenfelt
A1 Cesare de Filippo
A1 Kay Prüfer
A1 Susanna Sawyer
A1 Cosimo Posth
A1 Wolfgang Haak
A1 Fredrik Hallgren
A1 Elin Fornander
A1 George Ayodo
A1 Hamza A. Babiker
A1 Elena Balanovska
A1 Oleg Balanovsky
A1 Haim Ben-Ami
A1 Judit Bene
A1 Fouad Berrada
A1 Francesca Brisighelli
A1 George Busby
A1 Francesco Cali
A1 Mikhail Churnosov
A1 David E. C. Cole
A1 Larissa Damba
A1 Dominique Delsate
A1 George van Driem
A1 Stanislav Dryomov
A1 Sardana A. Fedorova
A1 Michael Francken
A1 Irene Gallego Romero
A1 Marina Gubina
A1 Jean-Michel Guinet
A1 Michael Hammer
A1 Brenna Henn
A1 Tor Hervig
A1 Ugur Hodoglugil
A1 Aashish R. Jha
A1 Rick Kittles
A1 Elza Khusnutdinova
A1 Toomas Kivisild
A1 Vaidutis Kučinskas
A1 Rita Khusainova
A1 Alena Kushniarevich
A1 Leila Laredj
A1 Sergey Litvinov
A1 Robert W. Mahley
A1 Béla Melegh
A1 Ene Metspalu
A1 Joanna Mountain
A1 Thomas Nyambo
A1 Ludmila Osipova
A1 Jüri Parik
A1 Fedor Platanov
A1 Olga Posukh
A1 Valentino Romano
A1 Igor Rudan
A1 Ruslan Ruizbakiev
A1 Hovhannes Sahakyan
A1 Antonio Salas
A1 Elena B. Starikovskaya
A1 Ayele Tarekegn
A1 Draga Toncheva
A1 Shahlo Turdikulova
A1 Ingrida Uktveryte
A1 Olga Utevska
A1 Mikhail Voevoda
A1 Joachim Wahl
A1 Pierre Zalloua
A1 Levon Yepiskoposyan
A1 Tatijana Zemunik
A1 Alan Cooper
A1 Cristian Capelli
A1 Mark G. Thomas
A1 Sarah A. Tishkoff
A1 Lalji Singh
A1 Kumarasamy Thangaraj
A1 Richard Villems
A1 David Comas
A1 Rem Sukernik
A1 Mait Metspalu
A1 Matthias Meyer
A1 Evan E. Eichler
A1 Joachim Burger
A1 Montgomery Slatkin
A1 Svante Pääbo
A1 Janet Kelso
A1 David Reich
A1 Johannes Krause
YR 2013
UL http://biorxiv.org/content/early/2013/12/23/001552.abstract
AB Analysis of ancient DNA can reveal historical events that are difficult to discern through study of present-day individuals. To investigate European population history around the time of the agricultural transition, we sequenced complete genomes from a ∼7,500 year old early farmer from the Linearbandkeramik (LBK) culture from Stuttgart in Germany and an ∼8,000 year old hunter-gatherer from the Loschbour rock shelter in Luxembourg. We also generated data from seven ∼8,000 year old hunter-gatherers from Motala in Sweden. We compared these genomes and published ancient DNA to new data from 2,196 samples from 185 diverse populations to show that at least three ancestral groups contributed to present-day Europeans. The first are Ancient North Eurasians (ANE), who are more closely related to Upper Paleolithic Siberians than to any present-day population. The second are West European Hunter-Gatherers (WHG), related to the Loschbour individual, who contributed to all Europeans but not to Near Easterners. The third are Early European Farmers (EEF), related to the Stuttgart individual, who were mainly of Near Eastern origin but also harbored WHG-related ancestry. We model the deep relationships of these populations and show that about ∼44% of the ancestry of EEF derived from a basal Eurasian lineage that split prior to the separation of other non-Africans.