PT  - JOURNAL ARTICLE
AU  - Chengfeng Xiao
AU  - Shuang Qiu
AU  - R Meldrum Robertson
AU  - Laurent Seroude
TI  - Tissue-specific downregulation of &lt;em&gt;EDTP&lt;/em&gt; removes polyglutamine protein aggregates and extends lifespan in &lt;em&gt;Drosophila&lt;/em&gt;
AID  - 10.1101/130559
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 130559
4099  - http://biorxiv.org/content/early/2017/04/26/130559.short
4100  - http://biorxiv.org/content/early/2017/04/26/130559.full
AB  - Drosophila egg-derived tyrosine phosphatase (EDTP, also called JUMPY) is a lipid phosphatase essential in the oogenesis and muscle function in the adult stage. Although mammalian JUMPY negatively regulates autophagy, loss-of-JUMPY causes muscle dysfunction and is associated with a rare genetic disorder centronuclear myopathy. Here we show that tissue-specific downregulation of EDTP in Drosophila non-muscle tissues, particularly glial cells, completely removes polyglutamine (polyQ) protein aggregates and improves survivor. Additionally, tissue-specific downregulation of EDTP in glial cells or motoneurons extends lifespan. We demonstrate an approach to fine-tune the expression of a disease-associated gene EDTP for the removal of polyQ protein aggregate and lifespan extension in Drosophila.