TY - JOUR T1 - Relationship between tumor grade and geometrical complexity in prostate cancer JF - bioRxiv DO - 10.1101/015016 SP - 015016 AU - J.A. Llanos-Pérez AU - E. Tejera-Puente AU - E. Izquierdo-Kulich AU - J.A. Betancourt Mar AU - M. Nistal AU - P. González-Peramato AU - M. Royuela-García AU - J.M. Nieto-Villar AU - M. P. De Miguel Y1 - 2015/01/01 UR - http://biorxiv.org/content/early/2015/02/08/015016.abstract N2 - Prostate cancer exhibits high mathematical complexity due to the disruption of tissue architecture. An important part of the diagnostic of prostate tumor samples is the histological evaluation of cellular and glandular organization. The Gleason grade and score, a commonly used prognostic indicator of patient outcome, is based on the match of glandular architectural patterns with standard patterns. Unfortunately, the subjective nature of visual grading leads to variations in scoring by different pathologists. We proposed the fractal dimension of the lumen and the Lempel-Zip complexity of the histopathological patterns as useful descriptors aiding pathologist to standardize histological classification and thus prognosis and therapy planning.geometrical complexity of prostate cancer ER -