RT Journal Article
SR Electronic
T1 Relationship between tumor grade and geometrical complexity in prostate cancer
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 015016
DO 10.1101/015016
A1 J.A. Llanos-Pérez
A1 E. Tejera-Puente
A1 E. Izquierdo-Kulich
A1 J.A. Betancourt Mar
A1 M. Nistal
A1 P. González-Peramato
A1 M. Royuela-García
A1 J.M. Nieto-Villar
A1 M. P. De Miguel
YR 2015
UL http://biorxiv.org/content/early/2015/02/08/015016.abstract
AB Prostate cancer exhibits high mathematical complexity due to the disruption of tissue architecture. An important part of the diagnostic of prostate tumor samples is the histological evaluation of cellular and glandular organization. The Gleason grade and score, a commonly used prognostic indicator of patient outcome, is based on the match of glandular architectural patterns with standard patterns. Unfortunately, the subjective nature of visual grading leads to variations in scoring by different pathologists. We proposed the fractal dimension of the lumen and the Lempel-Zip complexity of the histopathological patterns as useful descriptors aiding pathologist to standardize histological classification and thus prognosis and therapy planning.geometrical complexity of prostate cancer