PT - JOURNAL ARTICLE AU - J.A. Llanos-Pérez AU - E. Tejera-Puente AU - E. Izquierdo-Kulich AU - J.A. Betancourt Mar AU - M. Nistal AU - P. González-Peramato AU - M. Royuela-García AU - J.M. Nieto-Villar AU - M. P. De Miguel TI - Relationship between tumor grade and geometrical complexity in prostate cancer AID - 10.1101/015016 DP - 2015 Jan 01 TA - bioRxiv PG - 015016 4099 - http://biorxiv.org/content/early/2015/02/08/015016.short 4100 - http://biorxiv.org/content/early/2015/02/08/015016.full AB - Prostate cancer exhibits high mathematical complexity due to the disruption of tissue architecture. An important part of the diagnostic of prostate tumor samples is the histological evaluation of cellular and glandular organization. The Gleason grade and score, a commonly used prognostic indicator of patient outcome, is based on the match of glandular architectural patterns with standard patterns. Unfortunately, the subjective nature of visual grading leads to variations in scoring by different pathologists. We proposed the fractal dimension of the lumen and the Lempel-Zip complexity of the histopathological patterns as useful descriptors aiding pathologist to standardize histological classification and thus prognosis and therapy planning.geometrical complexity of prostate cancer