RT Journal Article
SR Electronic
T1 EPISTASIS AND ENTROPY
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 014829
DO 10.1101/014829
A1 Kristina Crona
YR 2015
UL http://biorxiv.org/content/early/2015/02/04/014829.abstract
AB Epistasis is a key concept in the theory of adaptation. Indicators of epistasis are of interest for large system where systematic fitness measurements may not be possible. Some recent approaches depend on information theory. We show that considering shared entropy for pairs of loci can be misleading. The reason is that shared entropy does not imply epistasis for the pair. This observation holds true also in the absence of higher order epistasis.