TY - JOUR T1 - Slingshot: Cell lineage and pseudotime inference for single-cell transcriptomics JF - bioRxiv DO - 10.1101/128843 SP - 128843 AU - Kelly Street AU - Davide Risso AU - Russell B. Fletcher AU - Diya Das AU - John Ngai AU - Nir Yosef AU - Elizabeth Purdom AU - Sandrine Dudoit Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/04/19/128843.abstract N2 - Single-cell transcriptomics allows researchers to investigate complex communities of heterogeneous cells. These methods can be applied to stem cells and their descendants in order to chart the progression from multipotent progenitors to fully differentiated cells. While a number of statistical and computational methods have been proposed for analyzing cell lineages, the problem of accurately characterizing multiple branching lineages remains difficult to solve. Here, we introduce a novel method, Slingshot, for inferring multiple developmental lineages from single-cell gene expression data. Slingshot is a uniquely robust and flexible tool for inferring developmental lineages and ordering cells to reflect continuous, branching processes. ER -