PT  - JOURNAL ARTICLE
AU  - Krishna Asvalayana
AU  - Samadhan Ghubade
AU  - Sharayu Paranjpe
AU  - Anil Gore
TI  - Model based safety ranking of opioid drugs using Adversity index
AID  - 10.1101/127530
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 127530
4099  - http://biorxiv.org/content/early/2017/04/14/127530.short
4100  - http://biorxiv.org/content/early/2017/04/14/127530.full
AB  - Annual ADR report counts of opioid drugs are examined to develop a candidate index of overall safety of a drug. Actual counts for various drugs have been sourced from www.vigiaccess.org. A feature found to be common to all drugs considered is that an exponential function adequately describes the pattern of cumulative counts. In the exponential model, the parameter in the exponent (rate constant) is robust and remains the same whether counts are corrected for exposure or not. We propose use of this rate constant as ‘adversity index’ of a drug. Drugs in use can be ranked by value of adversity index, lower value suggesting safer drug.Key points Cumulative total of annual ADR report counts of opioid drugs follows an exponential pattern. Rate constant in the model is independent of volume of use of the drug. Hence it is a suitable index of overall safety.