PT  - JOURNAL ARTICLE
AU  - Alessandro Giuliani
AU  - Masa Tsuchiya
AU  - Kenichi Yoshikawa
TI  - Single-Cell Genome Dynamics in Early Embryo Development: A Statistical Thermodynamics Approach
AID  - 10.1101/123554
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 123554
4099  - http://biorxiv.org/content/early/2017/04/13/123554.short
4100  - http://biorxiv.org/content/early/2017/04/13/123554.full
AB  - A statistical thermodynamics approach to the temporal development of biological regulation provides a phenomenological description of the dynamical behavior of genome expression in terms of autonomous self-organization with a critical transition (Self-Organized Criticality: SOC). In early mouse embryo development, the dynamical change in the self-organization of overall expression determines how and when reprogramming of the genome-expression state occurs. Reprogramming occurs via a transition state (climbing over an epigenetic landscape), where the critical-regulation pattern of the zygote state disappears. A critical transition is well captured in terms of the bimodality of expression ensembles, which reflects distinct thermodynamic states (critical states). These critical states exhibit a genome avalanche pattern: competition between order (scaling) and disorder (divergence) around a critical point. The genome avalanche in mouse embryo development, which is committed to erase a previous ordered state, reveals that the direction of early embryo single-cell development traverses the same steps as in differentiation, but in the opposite order of self-organization.