RT Journal Article SR Electronic T1 Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase JF bioRxiv FD Cold Spring Harbor Laboratory SP 117630 DO 10.1101/117630 A1 Christopher R. M. Asquith A1 Tuomo Laitinen A1 James M. Bennett A1 Paulo H. Godoi A1 Graham J. Tizzard A1 Jonathan M. Elkins A1 Timothy M. Willson A1 William J. Zuercher YR 2017 UL http://biorxiv.org/content/early/2017/04/11/117630.abstract AB 4-Anilinoquinolines were identified as potent and narrow spectrum inhibitors of the cyclin G associated kinase (GAK), an important regulator of viral and bacterial entry into host cells. Optimization of the 4-anilino group and the 6,7-quinoline substituents produced GAK inhibitors with nanomolar activity and over 50,000-fold selectivity relative to other members of the numb-associated kinase (NAK) sub-family. These compounds may be useful tools to explore the therapeutic potential of GAK in prevention of a broad range of infectious diseases.