RT Journal Article
SR Electronic
T1 Tissue adaptation: implications for gut immunity and tolerance
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 125641
DO 10.1101/125641
A1 Ana M. C. Faria
A1 Bernardo S. Reis
A1 Daniel Mucida
YR 2017
UL http://biorxiv.org/content/early/2017/04/08/125641.abstract
AB Tissue adaptation is an intrinsic component of immune cell development, influencing both resistance to pathogens and tolerance. Chronically stimulated surfaces of the body, in particular the gut mucosa, are the major sites where immune cells traffic and reside. Their adaptation to these environments requires constant discrimination between natural stimulation coming from harmless microbiota and food, and pathogens that need to be cleared. This review will focus on the adaptation of lymphocytes to the gut mucosa, a highly specialized environment that can help us understand the plasticity of leukocytes arriving at various tissue sites and how tissue-related factors operate to shape immune cell fate and function.