RT Journal Article
SR Electronic
T1 Modelling and Interpreting Network Dynamics
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 124016
DO 10.1101/124016
A1 Ankit N. Khambhati
A1 Ann E. Sizemore
A1 Richard F. Betzel
A1 Danielle S. Bassett
YR 2017
UL http://biorxiv.org/content/early/2017/04/04/124016.abstract
AB Recent advances in brain imaging techniques, measurement approaches, and storage capacities have provided an unprecedented supply of high temporal resolution neural data. These data present a remarkable opportunity to gain a mechanistic understanding not just of circuit structure, but also of circuit dynamics, and its role in cognition and disease. Such understanding necessitates a description of the raw observations, and a delineation of computational models and mathematical theories that accurately capture fundamental principles behind the observations. Here we review recent advances in a range of modeling approaches that embrace the temporally-evolving interconnected structure of the brain and summarize that structure in a dynamic graph. We describe recent efforts to model dynamic patterns of connectivity, dynamic patterns of activity, and patterns of activity atop connectivity. In the context of these models, we review important considerations in statistical testing, including parametric and non-parametric approaches. Finally, we offer thoughts on careful and accurate interpretation of dynamic graph architecture, and outline important future directions for method development.