PT  - JOURNAL ARTICLE
AU  - Jaak Simm
AU  - Günter Klambauer
AU  - Adam Arany
AU  - Marvin Steijaert
AU  - Jörg Kurt Wegner
AU  - Emmanuel Gustin
AU  - Vladimir Chupakhin
AU  - Yolanda T. Chong
AU  - Jorge Vialard
AU  - Peter Buijnsters
AU  - Ingrid Velter
AU  - Alexander Vapirev
AU  - Shantanu Singh
AU  - Anne Carpenter
AU  - Roel Wuyts
AU  - Sepp Hochreiter
AU  - Yves Moreau
AU  - Hugo Ceulemans
TI  - Repurposed high-throughput images enable biological activity prediction for drug discovery
AID  - 10.1101/108399
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 108399
4099  - http://biorxiv.org/content/early/2017/03/30/108399.short
4100  - http://biorxiv.org/content/early/2017/03/30/108399.full
AB  - We repurpose a High-Throughput (cell) Imaging (HTI) screen of a glucocorticoid receptor assay to predict target protein activity in multiple other seemingly unrelated assays. In two ongoing drug discovery projects, our repurposing approach increased hit rates by 60- to 250-fold over that of the primary project assays while increasing the chemical structure diversity of the hits. Our results suggest that data from available HTI screens are a rich source of information that can be reused to empower drug discovery efforts.