RT Journal Article SR Electronic T1 LncATLAS database for subcellular localisation of long noncoding RNAs JF bioRxiv FD Cold Spring Harbor Laboratory SP 116335 DO 10.1101/116335 A1 David Mas-Ponte A1 Joana Carlevaro-Fita A1 Emilio Palumbo A1 Toni Hermoso A1 Roderic Guigo A1 Rory Johnson YR 2017 UL http://biorxiv.org/content/early/2017/03/22/116335.abstract AB Background The subcellular localisation of long noncoding RNAs (lncRNAs) holds valuable clues to their molecular function. However, measuring localisation of newly-discovered lncRNAs involves time-consuming and costly experimental methods.Results We have created “LncATLAS”, a comprehensive resource of lncRNA localisation in human cells based on RNA-sequencing datasets. Altogether, 6768 GENCODE-annotated lncRNAs are represented across various compartments of 15 cell lines. We introduce “Relative concentration index” (RCI) as a useful measure of localisation derived from ensemble RNAseq measurements. LncATLAS is accessible through an intuitive and informative webserver, from which lncRNAs of interest are accessed using identifiers or names. Localisation is presented across cell types and organelles, and may be compared to the distribution of all other genes. Publication-quality figures and raw data tables are automatically generated with each query, and the entire dataset is also available to download.Conclusions LncATLAS makes lncRNA subcellular localisation data available to the widest possible number of researchers. It is available at lncATLAS.crg.eu.