TY - JOUR T1 - HUGIn: <span class="underline">H</span>i-C <span class="underline">U</span>nifying <span class="underline">G</span>enomic <span class="underline">In</span>terrogator JF - bioRxiv DO - 10.1101/117531 SP - 117531 AU - Joshua S. Martin AU - Zheng Xu AU - Alex P. Reiner AU - Karen L. Mohlke AU - Patrick Sullivan AU - Bing Ren AU - Ming Hu AU - Yun Li Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/03/16/117531.abstract N2 - Motivation High throughput chromatin conformation capture (3C) technologies, such as Hi-C and ChlA-PET, have the potential to elucidate the functional roles of non-coding variants. However, most of published genome-wide unbiased chromatin organization studies have used cultured cell lines, limiting their generalizability.Results We developed a web browser, HUGIn, to visualize Hi-C data generated from 21 human primary tissues and cell liens. HUGIn enables assessment of chromatin contacts both constitutive across and specific to tissue(s) and/or cell line(s) at any genomic loci, including GWAS SNPs, eQTLs and cis-regulatory elements, facilitating the understanding of both GWAS and eQTLs results and functional genomics data.Availability HUGIn is available at http://yunliweb.its.unc.edu/HUGIn.Contact yunli{at}med.unc.edu and hum{at}ccf.orgSupplementary information: ER -