RT Journal Article
SR Electronic
T1 HUGIn: <span class="underline">H</span>i-C <span class="underline">U</span>nifying <span class="underline">G</span>enomic <span class="underline">In</span>terrogator
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 117531
DO 10.1101/117531
A1 Joshua S. Martin
A1 Zheng Xu
A1 Alex P. Reiner
A1 Karen L. Mohlke
A1 Patrick Sullivan
A1 Bing Ren
A1 Ming Hu
A1 Yun Li
YR 2017
UL http://biorxiv.org/content/early/2017/03/16/117531.abstract
AB Motivation High throughput chromatin conformation capture (3C) technologies, such as Hi-C and ChlA-PET, have the potential to elucidate the functional roles of non-coding variants. However, most of published genome-wide unbiased chromatin organization studies have used cultured cell lines, limiting their generalizability.Results We developed a web browser, HUGIn, to visualize Hi-C data generated from 21 human primary tissues and cell liens. HUGIn enables assessment of chromatin contacts both constitutive across and specific to tissue(s) and/or cell line(s) at any genomic loci, including GWAS SNPs, eQTLs and cis-regulatory elements, facilitating the understanding of both GWAS and eQTLs results and functional genomics data.Availability HUGIn is available at http://yunliweb.its.unc.edu/HUGIn.Contact yunli{at}med.unc.edu and hum{at}ccf.orgSupplementary information: