@article {Martin117531, author = {Joshua S. Martin and Zheng Xu and Alex P. Reiner and Karen L. Mohlke and Patrick Sullivan and Bing Ren and Ming Hu and Yun Li}, title = {HUGIn: Hi-C Unifying Genomic Interrogator}, elocation-id = {117531}, year = {2017}, doi = {10.1101/117531}, publisher = {Cold Spring Harbor Laboratory}, abstract = {Motivation High throughput chromatin conformation capture (3C) technologies, such as Hi-C and ChlA-PET, have the potential to elucidate the functional roles of non-coding variants. However, most of published genome-wide unbiased chromatin organization studies have used cultured cell lines, limiting their generalizability.Results We developed a web browser, HUGIn, to visualize Hi-C data generated from 21 human primary tissues and cell liens. HUGIn enables assessment of chromatin contacts both constitutive across and specific to tissue(s) and/or cell line(s) at any genomic loci, including GWAS SNPs, eQTLs and cis-regulatory elements, facilitating the understanding of both GWAS and eQTLs results and functional genomics data.Availability HUGIn is available at http://yunliweb.its.unc.edu/HUGIn.Contact yunli{at}med.unc.edu and hum{at}ccf.orgSupplementary information:}, URL = {https://www.biorxiv.org/content/early/2017/03/16/117531}, eprint = {https://www.biorxiv.org/content/early/2017/03/16/117531.full.pdf}, journal = {bioRxiv} }