TY - JOUR T1 - Dynamic response to initial stage blindness in visual system development JF - bioRxiv DO - 10.1101/116590 SP - 116590 AU - Erping Long AU - Xiayin Zhang AU - Zhenzhen Liu AU - Xiaohang Wu AU - Xuhua Tan AU - Duoru Lin AU - Qianzhong Cao AU - Jingjing Chen AU - Zhuoling Lin AU - Dongni Wang AU - Xiaoyan Li AU - Jing Li AU - Jinghui Wang AU - Wangting Li AU - Haotian Lin AU - Weirong Chen AU - Yizhi Liu Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/03/14/116590.abstract N2 - Sensitive periods and experience-dependent plasticity have become core issues in visual system development. Converging evidence indicates that visual experience is an indispensable factor in establishing mature visual system circuitry during sensitive periods and the visual system exhibits substantial plasticity when facing deprivation. The mechanisms that underlie the environmental regulation of visual system development and plasticity are of great interest but need further exploration. Here, we investigated a unique sample of human infants who experienced initial stage blindness (beginning at birth and lasting 2 to 8 months) before the removal of bilateral cataracts. Retinal thickness, axial length, refractive status, visual grating acuity and genetic integrity were recorded during the preoperative period or at surgery, and then during follow-up. The results showed that the development of the retina is malleable and associated with external environment influences. Our work supported that the retina might play critical roles in the development of the experience-dependent visual system and its malleability might partly contribute to the sensitive period plasticity.SUMMARY STATEMENT The follow-up investigation of a group of human infants, who experienced initial stage blindness before the removal of bilateral cataracts, revealed that retinal development is associated with environment influences and its malleability might be a potential basis of plasticity. ER -