RT Journal Article
SR Electronic
T1 Psychiatric Genomics: An Update and an Agenda
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 115600
DO 10.1101/115600
A1 Patrick F Sullivan
A1 Arpana Agrawal
A1 Cynthia M Bulik
A1 Ole A Andreassen
A1 Anders D Børglum
A1 Gerome Breen
A1 Sven Cichon
A1 Howard J Edenberg
A1 Stephen V Faraone
A1 Joel Gelernter
A1 Carol A Mathews
A1 Caroline M Nievergelt
A1 Jordan Smoller
A1 Michael C O’Donovan
A1 for the Psychiatric Genomics Consortium
YR 2017
UL http://biorxiv.org/content/early/2017/03/10/115600.abstract
AB The Psychiatric Genomics Consortium (PGC) is the largest consortium in the history of psychiatry. In the past decade, this global effort has delivered a rapidly increasing flow of new knowledge about the fundamental basis of common psychiatric disorders, particularly given its dedication to rapid progress and open science. The PGC has recently commenced a program of research designed to deliver “actionable” findings - genomic results that (a) reveal the fundamental biology, (b) inform clinical practice, and (c) deliver new therapeutic targets. This is the central idea of the PGC: to convert the family history risk factor into biologically, clinically, and therapeutically meaningful insights. The emerging findings suggest that we are entering into a phase of accelerated translation of genetic discoveries to impact psychiatric practice within a precision medicine framework.Collaborators PGC Coordinating Committee: Mark Daly, Michael Gill, John Kelsoe, Karestan Koenen, Douglas Levinson, Cathryn Lewis, Ben Neale, Danielle Posthuma, Jonathan Sebat, and Pamela Sklar.