PT - JOURNAL ARTICLE AU - Patrick F Sullivan AU - Arpana Agrawal AU - Cynthia M Bulik AU - Ole A Andreassen AU - Anders D Børglum AU - Gerome Breen AU - Sven Cichon AU - Howard J Edenberg AU - Stephen V Faraone AU - Joel Gelernter AU - Carol A Mathews AU - Caroline M Nievergelt AU - Jordan Smoller AU - Michael C O’Donovan AU - for the Psychiatric Genomics Consortium TI - Psychiatric Genomics: An Update and an Agenda AID - 10.1101/115600 DP - 2017 Jan 01 TA - bioRxiv PG - 115600 4099 - http://biorxiv.org/content/early/2017/03/10/115600.short 4100 - http://biorxiv.org/content/early/2017/03/10/115600.full AB - The Psychiatric Genomics Consortium (PGC) is the largest consortium in the history of psychiatry. In the past decade, this global effort has delivered a rapidly increasing flow of new knowledge about the fundamental basis of common psychiatric disorders, particularly given its dedication to rapid progress and open science. The PGC has recently commenced a program of research designed to deliver “actionable” findings - genomic results that (a) reveal the fundamental biology, (b) inform clinical practice, and (c) deliver new therapeutic targets. This is the central idea of the PGC: to convert the family history risk factor into biologically, clinically, and therapeutically meaningful insights. The emerging findings suggest that we are entering into a phase of accelerated translation of genetic discoveries to impact psychiatric practice within a precision medicine framework.Collaborators PGC Coordinating Committee: Mark Daly, Michael Gill, John Kelsoe, Karestan Koenen, Douglas Levinson, Cathryn Lewis, Ben Neale, Danielle Posthuma, Jonathan Sebat, and Pamela Sklar.