%0 Journal Article %A Patrick F Sullivan %A Arpana Agrawal %A Cynthia M Bulik %A Ole A Andreassen %A Anders D Børglum %A Gerome Breen %A Sven Cichon %A Howard J Edenberg %A Stephen V Faraone %A Joel Gelernter %A Carol A Mathews %A Caroline M Nievergelt %A Jordan Smoller %A Michael C O’Donovan %A for the Psychiatric Genomics Consortium %T Psychiatric Genomics: An Update and an Agenda %D 2017 %R 10.1101/115600 %J bioRxiv %P 115600 %X The Psychiatric Genomics Consortium (PGC) is the largest consortium in the history of psychiatry. In the past decade, this global effort has delivered a rapidly increasing flow of new knowledge about the fundamental basis of common psychiatric disorders, particularly given its dedication to rapid progress and open science. The PGC has recently commenced a program of research designed to deliver “actionable” findings - genomic results that (a) reveal the fundamental biology, (b) inform clinical practice, and (c) deliver new therapeutic targets. This is the central idea of the PGC: to convert the family history risk factor into biologically, clinically, and therapeutically meaningful insights. The emerging findings suggest that we are entering into a phase of accelerated translation of genetic discoveries to impact psychiatric practice within a precision medicine framework.Collaborators PGC Coordinating Committee: Mark Daly, Michael Gill, John Kelsoe, Karestan Koenen, Douglas Levinson, Cathryn Lewis, Ben Neale, Danielle Posthuma, Jonathan Sebat, and Pamela Sklar. %U https://www.biorxiv.org/content/biorxiv/early/2017/03/10/115600.full.pdf