TY - JOUR T1 - Development of Narrow Spectrum ATP-competitive Kinase Inhibitors as Probes for BIKE and AAK1 JF - bioRxiv DO - 10.1101/094631 SP - 094631 AU - Rafael M. Couñago AU - Alison D. Axtman AU - Stephen J. Capuzzi AU - Hátylas Azevedo AU - David H. Drewry AU - Jonathan M. Elkins AU - Opher Gileadi AU - Cristiano R. W. Guimarães AU - Alessandra Mascarello AU - Ricardo A. M. Serafim AU - Carrow I. Wells AU - Timothy M. Willson AU - William J. Zuercher Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/03/02/094631.abstract N2 - Understanding the structural determinants of inhibitor selectivity would facilitate the design and preparation of kinase probes. We describe a pair of matched compounds differing only by one degree of saturation but showing dramatic differential activities at select kinases. We utilized x-ray crystallography and computational analysis to rationalize the basis of the differential activity. ER -