RT Journal Article SR Electronic T1 A maternal-effect genetic incompatibility in Caenorhabditis elegans JF bioRxiv FD Cold Spring Harbor Laboratory SP 112524 DO 10.1101/112524 A1 Eyal Ben-David A1 Alejandro Burga A1 Leonid Kruglyak YR 2017 UL http://biorxiv.org/content/early/2017/03/01/112524.abstract AB Selfish genetic elements spread in natural populations and have an important role in genome evolution. We discovered a selfish element causing a genetic incompatibility between strains of the nematode Caenorhabditis elegans. The element is made up of sup-35, a maternal-effect toxin that kills developing embryos, and pha-1, its zygotically expressed antidote. pha-1 has long been considered essential for pharynx development based on its mutant phenotype, but this phenotype in fact arises from a loss of suppression of sup-35 toxicity. Inactive copies of the sup-35/pha-1 element show high sequence divergence from active copies, and phylogenetic reconstruction suggests that they represent ancestral stages in the evolution of the element. Our results suggest that other essential genes identified by genetic screens may turn out to be components of selfish elements.