TY - JOUR T1 - Improving data availability for brain image biobanking in healthy subjects: practice-based suggestions from an international multidisciplinary working group JF - bioRxiv DO - 10.1101/110460 SP - 110460 AU - BRAINS (Brain Imaging in Normal Subjects) Expert Working Group AU - Susan D Shenkin AU - Cyril Pernet AU - Thomas E Nichols AU - Jean-Baptiste Poline AU - Paul M. Matthews AU - Aad van der Lugt AU - Clare Mackay AU - Linda Lanyon AU - Bernard Mazoyer AU - James P Boardman AU - Paul M Thompson AU - Nick Fox AU - Daniel S Marcus AU - Aziz Sheikh AU - Simon R Cox AU - Devasuda Anblagan AU - Dominic E Job AU - David Alexander Dickie AU - David Rodriguez AU - Joanna M Wardlaw Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/02/27/110460.abstract N2 - Brain imaging is now ubiquitous in clinical practice and research. The case for bringing together large amounts of image data from well-characterised healthy subjects and those with a range of common brain diseases across the life course is now compelling. This report follows a meeting of international experts from multiple disciplines, all interested in brain image biobanking. The meeting included neuroimaging experts (clinical and non-clinical), computer scientists, epidemiologists, clinicians, ethicists, and lawyers involved in creating brain image banks. The meeting followed a structured format to discuss current and emerging brain image banks; applications such as atlases; conceptual and statistical problems (e.g. defining ‘normality’); legal, ethical and technological issues (e.g. consents, potential for data linkage, data security, harmonisation, data storage and enabling of research data sharing). We summarise the lessons learned from the experiences of a wide range of individual image banks, and provide practical recommendations to enhance creation, use and reuse of neuroimaging data. Our aim is to maximise the benefit of the image data, provided voluntarily by research participants and funded by many organisations, for human health. Our ultimate vision is of a federated network of brain image biobanks accessible for large studies of brain structure and function. ER -