RT Journal Article
SR Electronic
T1 16GT: a fast and sensitive variant caller using a 16-genotype probabilistic model
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 111393
DO 10.1101/111393
A1 Ruibang Luo
A1 Michael C. Schatz
A1 Steven L. Salzberg
YR 2017
UL http://biorxiv.org/content/early/2017/02/24/111393.abstract
AB Summary 16GT is a variant caller for Illumina WGS and WES germline data. It uses a new 16-genotype probabilistic model to unify SNP and indel calling in a single variant calling algorithm. In benchmark comparisons with five other widely used variant callers on a modern 36-core server, 16GT ran faster and demonstrated improved sensitivity in calling SNPs, and it provided comparable sensitivity and accuracy in calling indels as compared to the GATK HaplotypeCaller.Availability and implementation https://github.com/aquaskyline/16GTContact rluo5{at}jhu.eduSupplementary information Supplementary tables and notes are available at Bioinformatics online.